Assessment of Serum Uric acid and Albumin among Sudanese Patients with Deep Venous Thrombosis

Abstract

Deep venous thrombosis (DVT) is a widespread medical trouble; the incidence that was estimated is 1-2 per 1000 person-years. Is related with elevated mortality in several thrombotic disorders, increased serum uric acid level and decreased albumin are a modest marker of increased DVT risk. This study conducted to assess the serum uric acid, and albumin in DVT patients. This is across- sectional study based on 50 DVT patients as cases, and 50 apparently healthy individuals as controls (age and gender were matched between two groups). The serum albumin and uric acid concentration was measured using Bio-system BTS-400 spectrophotometer. Platelets count performed using Sysmex cell counter. The data obtained was analyzed using statistical packaged for social science computer program (SPSS version 20). The level of albumin was significantly increased in DVT patients compared to control group (p-value = 0.000), while serum uric acid level was insignificantly different in both study groups ( p- value =0.929). According to gender, serum uric acid was insignificant different (p- value = 0.070), while albumin was significantly higher in female than male (p- value =0.013). There was significant decreased in platelets count in patients compared to control group ( p- value =0.000). The mean of APTT and PT were significantly prolonged in patients than control group (P – value = 0.000) (P – value = 0.001). In concerning to correlation, there were significant negative correlation between serum albumin , uric acid levels and ages of patients (r = -0.334 , p- value=0.018)( (r= -0.339 and p- value=0.016), respectively. There was no correlation between albumin, uric acid levels and duration of disease (r = -0.026, p -value=0.858). (r = -0.018 and p -value=0.903), respectively. The results of this study concluded that, serum albumin level is increased in patients with thrombosis and there was negative correlation between albumin, uric acid and ages of patients., and the platelet count is decreased.