Measurement of Prothrombin Time,Activated Partial Thromboplstin Time and Platelet Count among Gastrointestinal Bleeding Patients in Khartoum State

Abstract

Gastrointestinal bleeding or hemorrhage describes every form of hemorrhage (loss of blood) in the digestive tract from the mouth to the anus. Measurement of coagulation parameters is necessary to assess for continued bleeding.Abnormalities should be corrected rapidly. The study descriptive (Case Control) aimed to measurement coagulation profiles and Platelet count in gastrointestinal bleeding patients (GIB).The study conducted through the period from March 2020 to Nov 2020, in Mohammed Salih Idres Center for gastrointestinal bleeding in Ibn Sina Hospital in Khartoum State. The study population compromise two groups of adults in different age for both sex (66 males and 34 females) in age range from (20-85 years old). Two hundred subject were recruited for this study, hundred patients with acute gastrointestinal bleeding and hundred healthy volunteers as control group. The data was collected using laboratory investigation to obtain coagulation profile and platelet count results. Data collected using structured questionnaire which include general information and an verbal consent was obtained. Five ml of venous bloods were collected from all participants 2.5ml was added to trisodium citrate anticoagulant and 2.5ml was added in EDTA anticoagulant containers. The data analyzed by SPSS version 20. The data showed that about 66% of GIB patients were males and 34% were female. The Distribution of GIB patients according to age show that the mean age were 53±16.06 years The clinical manifestation of patients distributed as 49% with esophageal varices, 22% with Duodenal ulcer , 15% with gastritis and 14% with portal hypertension. The present study revealed significantly (P.V 0.000) lower PLT value in GIB patients compared with normal control. The PT,INR and APTT values were significally (P.V 0.000)and(P.V 0.000) higher in GIB patients compared to the normal control respectively, According to the causes of bleeding PT,INR and PLT count were significant increase in all causes has been studied P.value (0.007)(0.001)(0.00) respectively and there was no significant change on APTT P. value (0.563). The study concluded that the gastrointestinal bleeding patients may be at risk of thrombocytopenia, hemophilia and hypercoagulable state. Also the study proved the GIB have the quite similar effect in patients regardless of gender, age and history of bleeding although the males were more frequently affected by disease.