Effect of Garlic Oil on Prothrombin Time in the Blood of Healthy Adults

Abstract

This is crossectional study, conducted in Khartoum state to determine the effect of garlic oil on the prothrombin time during the period from November 2019 to March 2021. Garlic Oil derived from the crushed bulbs of garlic, the bulbs contain 0,06% to 0,1% of volatile oil whose active constituents are propyl/ -disulphide, alliin and allicin. Fifty (50) blood samples of healthy adult volunteers in this study; 22 of them were female and 28 were males, age ranged (21-30) years. In vitro anticoagulant effects of Garlic oil in different volumes (20% and 30%) were examined in blood samples of normal individuals by measuring prothrombin time (PT). The data were analyzed using statistical package for social sciences (SPSS), version 20.paired sample t-test was used to compare the mean of PT before and after adding garlic oil in different volumes. A P-value less than 0.05 was considered significant. The result showed that mean of PT before adding garlic oil was 13.6 seconds, and after adding garlic oil in different volumes(20% and 30%) were 23.9 and41.08 seconds respectively. was reflect that there is clear significant difference in PT (p. value 0.000). The results showed that mean of PT in both sexes before adding garlic oil were 13.6 for male, 13.5 for female and after adding garlic oil in different volumes (20% and 30%) were24.1for male, 23.7for female in post 20% and 44.0for male, 37.3for female in post 30% . was reflect that there is no significant difference between males and females in PT before adding garlic oil and after adding 20% garlic oil (P. value 0.765 , 0.671) respectively, but there is significant difference between males and females in PT after adding 30 % garlic oil to samples( p.value0.002). The results showed that No statistically significant difference was found in the two aged Group before and after adding Garlic oil in different volumes (20% and 30%), p.value (= 0.919 , 0.692 and 0.703) respectively. This study was concluded that the prothrombin time was affected when adding garlic oil among healthy volunteers samples.