Abstract:
Metabolic syndrome represents a cluster of metabolic abnormalities that include hypertension central obesity, insulin resistance, and atherogenic dyslipidemia, this cross sectional study was carried out to investigate the level of triglycerides, HDL-C and triglycerides to HDL-C ratio among Sudanese metabolic syndrome patients in Khartoum State 2019.
A total of 80 participants were included in this study, forty blood samples were randomly collected from metabolic syndrome patients as case group and forty blood samples were collected from patently healthy individual as control group during the period from April to August. The estimation of serum triglycerides and HDL-C was done by using biosystems BTS-305, and then results were analyzed by using SPSS computer program.
Statistical analysis showed a significant increase of body mass index (BMI) in metabolic syndrome patients (mean±SD: 30.80±6.2) when compared to control (24.1±3.5) p- value = 0.000, and a significant increase in waist circumference( WC) in metabolic syndrome patients (mean±SD: 110±11) when compared to control (83.2±11.5) p-value = 0.00, and a significant increase in triglycerides levels in metabolic syndrome patients (mean±SD: 119.8±78) when compared to control (83.9±38.2) p- value = 0.011,and Insignificant difference HDL-C levels in metabolic syndrome patients (mean±SD: 51.1±26.9) when compared to control (52.4±14.4) p- value = 0.78 and significant increase in TG/HDL-C ratio in metabolic syndrome patients (mean±SD: 2.9±2.9) when compared to control (1.6±.84) p-Value = 0.026. Statistical analysis also showed insignificant difference in BMI, WC, systolic blood pressure (SBP), diastolic blood pressure (DBP), triglycerides, HDL-C and TG/HDL-C ratio in males of metabolic syndrome compared to females
Statistical analysis also showed insignificant difference in BMI, WC, SBP, DBP, triglycerides, HDL-C and TG/HDL-C ratio according to duration of metabolic syndrome from (˂ 1) (1-5), (>5) year respectively, and according to physical activity (In active) (˂100), (100-150) minute respectively.
Statistical analysis also showed the associate between odd ratios of weight reduction for TG, HDL-C, TG/HDL-C ratio in metabolic syndrome patients, the odd ratios and p-values respectively as follow: for triglycerides (0.5, p-value=0.216) for HDL-C (1.1, p-value=0.437) for TG/HDL-C (0.89, p-value =0.430).
In conclusion: Metabolic syndrome patients had higher level of serum triglycerides, triglycerides to HDL-C ratio, the value of BMI, WC, while the level of HDL-C is had no difference, and level of triglycerides, HDL-C and triglycerides to HDL-C ratio, the value of BMI WC, SBP , and DBP were no difference in males compered to females in metabolic syndrome patients, also were no according to physical activity and duration in metabolic syndrome patients ,moreover level of triglycerides and triglycerides to HDL-C ratio is not associated by weight reduction, while the level of HDL-C was associated by weight reduction.
