Abstract:
At the present research the effect of heat and storage condition was studied and investigated for Three group of commercial aspirin (acetyl salicylic acid) samples from different market in Khartoum state (Omdurman, Bahrie, Khartoum). The obtained samples were subjected to physical and chemical tests using different analytical techniques. The average weight of sample of Khartoum was 0.326g, Omdurman and ,Bahrie were 0.325g, 0.334g respectively. The average hardness were found of sample of Khartoum 3.005kg, Omdurman 3.065kg, Bahrie 3.395kg (Reference hardness not more than 10 and not less than 4kg). The average thickness of sample were also measured and it was found for Khartoum 3.1mm, Omdurman 3.15mm , Bahrie .15mm (Reference thickness not more than3.2mm). The result of average friability of sample of Khartoum 1.15%, Omdurman 1.35%, Bahrie 1.15% , (Reference friability not more than 1%). The obtained results showed that the dissolution were 63.86% for Khartoum sample and 63.70%, 66.20% for Omdurman and Bahrie respectively (Reference more than 75%). Finally the average assay of Khartoum was found 83.713% , Omdurman 78.56%, Bahrie 84.593% (Reference according to Britches pharmacopeia 98±102%) From the above obtained results in this research its clear that the aspirin marketed in the street in local market was less effective.
