Assessment of Albumin: Creatinine Ratio and Estimated Glomerular Filtration Rate among Hypertensive Patients at Al-Jazeera State

Abstract

hypertension has much serious effect on human body and cause different diseases such as coronary heart disease, cerebrovascular disease and chronic kidney disease. This study conducted to determine the albumin creatinine ratio and eGFR in Sudanese hypertensive patient at Al-Gezera state. The study hypothesized that there is no difference in albumin: creatinine ratio and eGFR levels between hypertensive patients and normotensive group. This hypothesis was tested by cross sectional comparative study during the period from September 2019 to November 2020. The study was included 60 hypertensive patients and 40 normotensive individuals. A structured questionnaire was designed to obtain demographic and clinical data. Urine samples were collected from all participants in clean urine container, then investigated for levels of urine albumin and urine creatinine by using full-automated cobas system international analyzer in Al-Gezera Hospital for Renal Diseases and Surgery to calculate albumin: creatinine ratio. Venous blood samples were collected from all participants in heparin-containing container and investigated for plasma creatinine level using automated biosystem biochemical system international analyzer in AL-Daraga center to calculate eGFR. The results showed that, significant (p <0.05) increased difference in albumin: creatinine ratio and significance (p <0.05) decreased difference in eGFR in hypertensive patients when compared to normotensive group was found, the level of was increased in uncontrolled hypertensive patients and in hypertensive patients had DM and also found the level of eGFR was decreased in >61year age and in>8 years’ duration of hypertension. Therefore, albumin: creatinine ratio and eGFR had associated with hypertension