Abstract:
This is a case- control study aimed to evaluate some hematological parameters in patients under treatment with antiepileptic drugs and in normal control subjects in Khartoum state during period from March to December (2019).
Hundred subjects, selected randomly in this study, with age varies from 10-60 years, 50 subjects were epileptic patients (26 males and 24 female) as case group and 50 subject (25 males and 25 female) were age and sex matched healthy control group. The age grouped in three age groups and age group (10-25 year) high frequent in both case and control 25(50%), 31(62%). Followed by age group (26-50 year) in case and control 19(38%), 15(30%), followed by age group (>50year) low frequent in both case and control 6(12%), 4(8%) respectively. Venous blood (3ml) was collected in ETDTA container from each subject. Hematological analyzer (Sysmex KX 21N) was used for complete blood count. Statistical analysis was performed using Statistical Package for Social Science (SPSS) program version 22. The data display as mean ± SD, frequency, person correlation, one-way ANOVA test and P. value ≤ 0.05.
There was no statistical correlation between levels of Hb and MCHC in both case and control p. value 0.055 and 0.82 respectively. Statistically there was significant correlation in MCV and MCH level between case and control p. value was 0.03 and 0.011 respectively.
There was insignificant relationship between Hb, MCHC and type of treatment p. value 0.992 and 0.66. but there was significant relation between MCV, MCH and type of treatment p. value 0.027 and 0.042 respectively. Post-hoc using LSD test was conducted, showed significant correlation with Na valproate and phenytoin p. value 0.11 and 0.26 respectively. There was no statistical correlation between Hb level and dose and duration of treatment p. value 0.413 and 0.911 respectively.
The study concluded that estimation of hematological parameters, vitamin B12 level and folic acid level be strictly monitored regularly in individuals administered antiepileptic drugs for long period.
