Antidiabetic Activity of Origanum Majorana L in Glucose Fed Normal Rats and Alloxan-Induced Diabetic Rats

Abstract

Glycemic management medications have become increasingly complex and controversial. Plant-based traditional medicine has been proven worldwide as alternative treatment for diabetes.To evaluate the antidiabetic efficiency of Origanum majorana L extracts in normal and diabetic rats.Diabetes (Type 1 and type 2) were induced by administration of single intraperitoneal dose of 150 mg/kg of alloxan and ingestion of 20 mg/km of 50% w/v glucose once a day for 30 days respectively. The aqueous and methanolic extracts of O. majorana L was prepared and given to diabetic and hyperglycemic rats at 250 and 500 mg/kg/day orally for 30 days. Oral glucose tolerance test (GTT) was conducted in normal healthy rats using single dose of 350 mg/kg of each extract. At 30-day blood samples were collected for biochemical analysis. The result shows that alloxan induced diabetic groups treated with plant extracts had significantly lower fasting glucose level and glycosylated haemoglobin and improved lipid profile, insulin concentration was insignificantly changed. Blood glucose and cholesterol values were significantly decreased in glucose loaded rats treated with water extract at low dose. This study suggests that aqueous and methanolic extracts of O. majorana possess a potential antidiabetic activity for both type1 and type2 diabetes.