Assessment of renal funtion tests among patients with rheumatoid arthritis in Khartoum state

Abstract

Background: Rheumatoid arthritis patients had higher risk of developing chronic kidney disease and glomerulonephritis which increase mortality with a hazard ratio (HR) of 2.77-4.45. Objective: The aim of this study is to assess urea ,creatinine , sodium and potassium levels in rheumatoid arthritis patients . Materials of Methods: This comperative study was conducted at Military Hospital in Khartoum State, the study carried out on a total sample of 100 individual s including 50 with Rheumatoid arthritis patients as case and 50 healthy individuals as control group. Serum urea and creatinine levels were estimated using spectrophotometer biosystem-310, analyze. Sodium and potassium were estimated by easy light. Data analyzed were using SPSS software program version 20. Results: This study showed that, the levels of urea and creatinine were significantly increased in rheumatoid arthritis patients with (43.64± 15.78 versus 26.86±7.65 mg/dl, P value = 0.000 ) for urea and (1.31±0.795 versus 0.736±0.179 mg/dl , P value = 0.000 ) for creatinine, while there was no difference in level of sodium (136.9±18.31 versus 140.1±4.36 mmol/l with P value 0.214) and potassium(3.96±0.556versus 3.95±0.42mmol\l with p.value0.785). There was modrate positive correlation between urea levels with age (R 0.644, P. value 0.000). While there were no correlation between creatinine, Na and K with age (R -0.042, P value= 0.773. R 0.034, P value= 0.813.R -0.069, P value =0.632 respectively). Also, there were no correlation between urea , creatinine Na and K with duration (R 0.003, P value= 0.986.R 0.094, P value= 0.515.R 0.147, P value= 0.310 .R 0.072, P value= 0.620 respectively). In Conclusion: From the results and finding of this study, it is concluded that: The serum levels of urea and creatinine are higher in Rheumatoid arthritis patients, and there are no observed difference in Na and K concentratin in Rheumatoid arthritis patients and the increase of urea levels is correlated directly with age.