Iron Profile and Hemoglobin Concentration among patients with Chronic Renal Failure on Hemodialysis in Khartoum

Abstract

Anaemia is common in patients with chronic renal failure specially in patients on haemodialysis. An important factor in successful treatment of anaemia by giving erythropoietin stimulating agent combined with iron supplement .so, iron status must be monitored regularly to ensure maintain of adequate iron supplement Without adverse effect of excess iron(Allen and Nissenson,1999). This study aimed to assess body iron status and measurement of haemoglobin concentration in Sudanese patients at end stage chronic renal failure treated with regular haemodialysis,iron supplement and recombinant erythropoietin, and correlate iron profile with gender, age and duration of dialysis. A total of Hundred Sudanese patients (80 chronic renal failure patients under haemodialysis and 20 healthy control) were Included in this study from dialysis department in Khartoum states (Omdurman military teaching hospital). 53% of patients enrolled in the study were male and 47% were female, their age ranged between 18 to 85 years. Data collected using structured interview questionnaire. Serum iron, serum ferritin and total iron binding capacity measured using DIRUICS-T240 auto chemistry analyzer. haemoglobin concentration was measured by using automated haematological analyzer (sysmex).Data analyzed using statistical package for social sciences (spss). 64% of patients were found with high s.ferritin level with more than 400Mg/L,The mean was)615±245.8(.and high serum iron with mean (86.39±52.148). Seventy two of patients out of hundred were found to have anaemia,the mean of haemoglobin was )8.96±1.5(, .this study showed lowered level of TIBC with mean (176.25±69.89,p-value0.000). The present study showed that the serum iron and serum ferritin of those under haemodialysis patients were significantly higher compared to the control group with p value 0.001 and 0.000 as respectively. There were no influence of patients age or gender on iron profile. In conclusion patients with chronic kidney disease who were treated with intravenous iron are prone to iron over load