Assessment of Plasma Uric acid and Magnesium Levels in Sudanese Patients with Rheumatoid Arthritis in Khartoum State

Abstract

Background and aim of study: Rheumatoid arthritis is an autoimmune disorder, which causes chronic inflammation of the joints. Rheumatoid arthritis patients had higher risk of developing chronic kidney disease and chronic cardiovascular disease, Objectives: The Aim of this study to evaluate the plasma levels of magnesium and uric acid in rheumatoid arthritis patients. Materials and Methods: this was cross sectional-case control study conducted during the period from June to October 2019, the study carried on a total sample of 100 individual including 50 patients with rheumatoid arthritis already diagnosis as case and 50 healthy individual as control group. Plasma magnesium and uric acid were measured by using spectrophotometer biosystem-310 , xylidyl blue reagent for magnesium and enzymes for uric acid analyze and results were analyzed using statistical of package social science (SPSS) computer program. Results: this study showed plasma magnesium and uric acid were significantly increase among rheumatoid arthritis patients(cases) versus healthy individual(control), mean ±SD values of plasma magnesium (mg/dL) was (2.95±0.91) versus (2.26±0.39) with P-value (0.000), plasma uric acid (mg/dL) was (4.82±1.36) versus (3.66±1.05) with P- value (0.000), all the differents were statistically significant. There were insignificant correlation between uric acids, magnesium and study variables (age and duration of disease), (r= 0.233, p-value= 0.101), (r= 0.014, p .value=0.925) respectively, and ( r=0.080, P value= 0.582), (r= 0.076, P value= 0.600) respectively. Conclusion: In rheumatoid arthritis patients plasma magnesium and uric acid are higher.