Estimation of Prothrombin Time, Activated Partial Thromboplastin Time among Hypertensive Patients in AL-Gezira State during period from March to May 2019

Abstract

This is a case control study to estimate Prothrombin Time, Activated Partial Thromboplastin Time among hypertensive patients in AL- Gezira state at the period from March to May 2019. A total of 100 subjects were enrolled for this study, study population divided into case study group (n=50) who were hypertensive patients, and apparently healthy subjects as control group (n=50). Both, they're matched in age and sex. Venous blood sample (1.8ml) was collected in 3.2% tri sodium citrate container from each participant. Then, plasma was separated by Centrifugations for 15 minutes, estimation of coagulation profile (PT, APTT) was performed by using coagulometer device (BT3505C192) and obtains data by (SPSS) program Version 20 was used for data analysis. The result obtained from patient that the mean of PT, APTT in case were (14.3 sec), (30.1sec) respectively and compare to mean of PT, APTT were (13.2 sec), (29.7 sec) respectively in control with significant difference for PT (p.value=0.00) and no significant difference for APTT (p.value=0.71). The study concluded that the prothrombin time is effected and Activated partial thromboplastin time is no effected by Hypertension.