Association of Diabetes Mellitus Type2 with ABO¬ and A Subgroup and Rhesus D Blood Group in Khartoum State

Abstract

This was an analytical case control study, conducted in Al Waledain health center in Burri Al Lamab in Khartoum state, during the period from August to November 2019 . Aimed to investigate the association of Diabetes mellitus type2 with ABO and A sub group and Rhesus D blood groups in Khartoum state . Total of 100 subjects are involved in this study 50 diabetic type2 subjects as case and another 50 non diabetic subjects as control matching in age and sex . Three ml of EDTA anticoagulated blood was taken , Slide agglutination test for the determination of ABO and A subgroup and Rhesus D blood groups were used , Du technique was performed to Rhesus negative results . Data were analyzed by using SPSS program version 20 , chi square test and correlation was calculated to show any association of diabetes mellitus type2 with ABO and A subgroup and Rhesus blood groups. The study include both sexes with 43/100( 43%) male while 57/100( 57%) was female. The mean age of case was ( 51.44 ± 13.824 ) years and in the control was ( 43.60 ± 17.287) years . The percent of sex in case male was ( 21%) , and female was ( 29% ) , and in control male was ( 22% ) and female was ( 28% ) . The distribution of ABO blood group of both case and controls group was O( 23% vs 24% ) , A1( 20% vs 14 ) , B( 7% vs 9% ) , A1B(0% vs 2%) , A2B( 0% vs1%) ,( p.value = 0.436 ) the results showed there was no significant variation in the distribution of ABO blood group between type2 diabetic subjects and control . Also no significant variation (p.value = 0.647 ) was found in the frequency of Rhesus with type2 diabetic subjects . The O blood group give risk factor for diabetes mellitus type2. There was strong positive correlation between age of case and control groups ( sig = 0.00 , r = 0.844 ) . and negative correlation between age and sex among case and control ( sig = 0.370 , r = - 0.091 ). Finally conclude there was no association between ABO and A sub group / Rhesus factor with diabetes mellitus type2.The O blood group was risk factor for diabetes mellitus type2. And there was strong positive correlation between age of case and control and negative correlation between age and sex among case and control .