Assessment of Complete Blood Count and Iron Profile Among Sudanese Patients with Depressive Disorders

Abstract

Depressive disorders, a group of illnesses characterize by Depression for a long period of time and Loss of interest in activities which causes serious physical and social dysfunction in individuals and severely disrupt the person’s life. This is a cross-sectional study intended to evaluate of complete blood count and iron profile among Sudanese patients with depressive disorders in Omdurman, Sudan. Short questionnaire was administered on the randomly chosen, and fifty blood samples were collected and performed complete blood count (CBC), blood film and iron profile for each participant. The data was entered and analyzed by SPSS program (version 16) and compared with international studies. The Result showed that CBC parameters were normal comparing with reference value as follows: RBCs (Mean = 4.75vs. 4.2-6.1×1012/L), Hb (Mean = 13.2vs. 12-18 g/dl), HCT (Mean = 42.44vs. 37-54 %), MCV(Mean = 89.33vs. 80-96 fl), MCH(Mean =27.73vs. 27-32 pg.) , MCHC(Mean = 31.11vs. 32-36 g/dl), platelets count (Mean = 227.64 vs. 145-400 ×109/L), TWBCs (Mean =5.5 vs. 4.0-10.0 ×109/L), Serum iron (Mean = 16.47 vs. 7.16-31.3 mmol/L), Ferritin (Mean = 89.97 vs. 20-250 µg/L), TIBC (Mean = 60.02 vs. 36-72 µmol/L), Transferrin Saturation (Mean = 27.96 vs. 20-50 %). The association between severity of depression and low Hb level is significant (P. Value= 0.007). The association between severity of depression and iron deficiency anemia was insignificant (P. Value= 0.951). We concluded that normal complete blood count and iron profile noted in majority of depressed patient with statistical significant in all hematological parameters except MCV, Mix, and TIBC which statistical insignificant in depressed patients when compared with mean of reference values, and there is a relation between low hemoglobin level and depressive disorders while there is no relation between iron deficiency anemia, socio-demographic factors with severity of depressive disorders.