Determination Of Complete Blood Count ,Urea ,Creatinine And Calcium Among Chronic Renal Faliure Before Dialysis

Abstract

Renal failure means faliure of renal excreatory function due to depression of glomular filtration rate. This accompanied to variable extent by failure of erythropoietin production ,vitD hydroxylation , regulation of acid base balance and regulation of salt and water balance and blood pressure .renal failure is associated with a variety of haemopoietic change.This is case control study aimed to determine the complete blood count, urea creatinine and calcium values in chronic renal failure patients(CRF),100 subject were recruited for this study, fifty patients with renal failure from Atbara Nori dialysis center and fifty healthy controls were enrolled. Patient data were collected from patient medical files and by questionnaire,2.5 ml of blood were collected from all participant in EDTA and 2.5ml of blood collected in lithumheparine container. Sample in EDTA is used to measure haemoglobin concentration ,Hct,RBCs and platelet using Haematological analyzer (Mindary bc3000)and samples in lithumheparine were used to measure urea, creatinine and calcium using chemical Analyzer (A15).The data Analyzed by SPSS version 15..Means Hb,Hct,RBCs and platelet were significally lower in the renal failure patients than in controls(P.value ≤0.000 ,0.000.0.000and 0.03) respectively but mean of twbcs was nonsignifically higher than controls(P.value≤ 0.653).Hb and RBCs were significantly decreased with increased the duration of renal failure disease (P.value≤ 0.000 and 0.000) respectively. Mean urea and creatininewere significantly higher than controls(P.value≤ 0.000 and 0.000respectively),calcium was not affected and recorded normal result (P.value≤ 0.137). In this study we observed that male suffering from CRF (64%) is more than female (36%) ,the distribution of CRF patients according to age recoded (60%) for the age from (41-60) years then (26%) for age from 21-40 Then(14%)for age more than 60. The distribution of CRF patients according to causes of CRF High percentage (64%) in hypertension then diabetes (20%) then other cause (16%).More studies must be done confirm these results and screening program should be done to reduce the risk and to prevent complication of chronic renal failure.