Detection of Cytomegalovirus IgM Antibodies among Sudanese Hepatitis B Patients in Khartoum State

Abstract

Human Cytomegalovirus (CMV) is one of the most commonly found agents of congenital infections. Primary maternal infection is associated with risk of symptomatic congenital diseases.

This study was aimed for detection of CMV antibodies in serum of hepatitis B patients in Khartoum state using enzyme linked immunosorbant assay during the period from March to November 2019. Blood specimen was collected from 88 hepatitis B patients formed 48 (54.5%) male and 40 (45.5%) female with age ranging (10-50) years. Personal and clinical data were collected by questionnaire after verbal concent, All specimens were tested for the presence of CMV IgM antibodies using ELSIA kit.CMV IgM antibodies were detected in 12 (13.6%) of the total specimen examined. The rate of anti HCMV IgM antibodies sero-positivtity among male 7 (8.0%), while the rate of anti HCMV IgM seropositive among females were 5 (7.5%). The highest positive cases were in hepatitis B patient’s age 20-30 years.

Eight (9.1%) of hepatitis B patients had history of previous blood transfusion, and 5 (5.7%) of them shows symptoms of jaundice. From all cases 44 were chronic HBV patients while 44 were acute HBV patients. 28 (31.8%) of all cases had treatment for HBV.

The finding of this study indicates low frequency of CMV among HBV patients. There was no correlation of serological finding of CMV and age of patient.