Assessment of Anti-Mullerian hormone, Fertility Hormones (LH, TSH, prolactin and testosterone) and Leptin Hormone Among obese with Poly cystic ovary Syndrome

Abstract

Polycystic ovarian syndrome (PCOS) is a complex endocrine disorder and is the leading cause of infertility, affecting approximately six to eight percent of reproductive-age women and is associated with obesity. Anti-Müllerian hormone (AMH) has been a marker tool for diagnosis of PCOS and fertility beside fertility hormones. So this study concerned about PCOS, fertility hormones among obese infertile women compared with obese fertile ones. They were at reproductive age, recruited in Khartoum state fertility centers. Whole blood samples were collected and assessed for AMH, luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone and prolactin as they were obese. Comparing measured parameters between PCOS obese women and control group contained fertile obese women, revealed increased levels of all parameters among PCOS obese women, except FSH. Anti-müllerian hormone (AMH) levels showed increased levels among women with PCOS was to be 9.20 Pmol and 2.99P mol/l for obese control A significant difference (p=0.000) was found between obese and non-obese groups. The average concentration for leptin was 24.8ng/ml for obese control, 34.5ng/ml for obese PCOS. A significant difference (p=0.000) in the average concentration was found between obese and non-obese groups.