Serum Gamma GlutamylTranspeptidase and Alkaline Phosphatase Levels among Metabolic Syndrome Patients in Khartoum State

Abstract

Metabolic syndrome is a serious medical condition, increase incidence of multiple cancers risk, has effects on the life quality, it is a problem found all over the world and Sudan and it’s fatal unless controlled and treated properly. This study was conducted to assess serum alkaline phosphatase and γ- glutamyle transpeptidase in patients with metabolic syndrome. Hundred blood samples were collected during period from June to July 2018, chosen randomly from Aliaa Specialized Hospital in Khartoum State, 50 apparently healthy individuals serves as control group. Serum alkaline phosphatase and γ- glutamyle transpeptidase were measured using enzymatic method Cobas Integra 400 Plus (full automation instrument). The results were analyzed using statistical package for social science (SPSS version 23) computer program. The study showed that, there were significant increase in mean of GGT, ALP and BMI of cases versus control.( mean± SD; 47.08 ± 35.808 versus 25.48 ± 9.132 IU/L, p- value= 0.00), (85.26 ± 30.370 versus 60.24 ± 15.533 IU/L, p- value= 0.00), (28.030 ± 3.6350 versus 22.770 ± 1.686 kg/m2, p- value= 0.00) respectively. The study showed that, metabolic syndrome most common among age group (40-54) years (54%) and most abundant in females (62%) than males (38%). The study also showed, there was no correlation between GGT level and study variables (BMI, duration and age) of metabolic syndrome in patients group; (r= 0.118 P- value = 0.415), (r=0.081, P- value=0.575), (r=0.024, P- value=0.869) respectively.

The study showed there was significant weak positive correlation between ALP level and BMI of metabolic syndrome in patients group; (r =0.301, P- value=0.034), while there was no correlation between ALP level and duration and age of metabolic syndrome in patients group; (r =0.103, P- value=0.478) and (r =0.124, P- value=0.392) respectively. The study concludes that; patients with metabolic syndrome had higher level of GGT and ALP. The metabolic syndrome is more common in females than males, more over is more in frequent in age 40-54 years old.