Assessment of Testosterone , LDL and HDL Cholesterol among Females with Polycystic Ovary Syndrome

Abstract

Background: Polycystic ovary syndrome is a heterogeneous endocrine disorder which affects 5–15% of the general population, depending on the ethnicity and the applied classification system, Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age It is characterized by polycystic ovaries, oligo-amenorrhea, and hyperandrogenism. Objective: The aim of this study is to assess testosterone, HDL-c and LDL-c in patients with polycystic ovary syndrome (PCO). Methods: This cross sectional study was conducted at Alsir Abu Hassan center for fertility in Khartoum State, the study carried out on a total sample of 100 females including 50 females with polycystic ovary syndrome patients as case and 50 healthy females as control group. Serum testosterone levels was estimated using Enzyme linked immune sorbent assay technique and serum HDL-c, LDL-c level was estimated using spectrophotometer biosystem-310 . Data analyzed using SPSS software program version20. Results: This study showed that the levels of testosterone was significantly increased with (p-value 0.000); while there was insignificant elevation in level of HDL-c, LDL-c with ( p-value HDL-c(0.412)and p-value LDL-c(0.957)) in polycystic ovary syndrome patients compared to control group. When comparing polycystic ovary syndrome patients according to menstrual regulation, infertility, duration , family history, cosmetics and take of medication the study showed that there was significant increase in testosterone across menstrual regularity ,duration, infertility , family history, cosmetics and take of medication with (p-value 0.000) , and insignificant deference in HDL-c LDL-c across menstrual regularity with (p-value 0.130)(p-value 0.207) infertility with (p-value 0.208) (p-value 0.254),, family history with (p-value 0.708)(p-value 0.254), cosmetics with (p-value 0.159)(p-value 0.320) and take of medication with (p-value 0.571) (p-value 0.574). There was no correlation between testosterone levels with age, and body mass index (R -0.177 P. value 0.218, R -0.554 P. value 0.708) and negative correlation with duration (R -0.562 P. value 0.002) respectively. Also, there was no correlation between HDL-c with duration, body mass index and with age (R 0.011 P. value 0.756** R -0.06 P. value 0.679**R -0.246 P. value 0.085) respectively and no correlation between LDL-c with duration ,body mass index with (R 0.460 P. value 0.756** R 0.294 P. value 0.38) , and weak positive correlation with age with ( R 0.321 P. value 0.023). Conclusion: From the results and finding of this study, it is concluded that: The serum levels of testosterone are higher in PCOs female patients, and there are observed change in HDL-c and LDL-c concentration PCOs female patients. No correlations were found between BMI and age and serum levels of testosterone HDL-c and LDL-c . No correlations were found between duration and serum levels of HDL-c and LDL-c ,and negative correlation between duration and testosterone level.