Abstract:
Chlamydia trachomatis is recognized as one of the most common sexually transmitted pathogen in the world, most infected female are asymptomatic. These untreated women are at risk of developing chronic sequelae leading to tubal pathology causing infertility. The aim of this study to detect the anti-Chlamydia trachomatis IgG among infertile women with blocked Fallopian tube and pregnant women and to determine the associatation between Chlamydia trachomatis and tubal blockage.
Sixty infertile women with blocked Fallopian tube diagnosed by Hysterosalpingography (HSG) attending fertility centers in Khartoum state and 30 pregnant women were included in this case control study during the period from July to December 2018.
Anti-Chlamydia trachomatis IgG was investigated by Enzyme Linked Immunosorbent Assay (ELISA). Infertile women with blocked Fallopian tube and pregnant women were compared and the data were statistically analyzed by Statistical package for the Social Sciences (SPSS) version 16.
The study showed that there was greater prevalence of chlamydia trachomatis infection in infertile women with blocked Fallopian tube (18.9%) compared pregnant women (1.1%), the different was found statistically highly significant (p value= 0.005). The prescence of Chlamydia is associated with 11.46 fold risk of tubal blockage (OR: 11.46, 95%CI:1.44-90.95, P=0.002). Also showed the significant high prevalence of chlamydia trachomatis IgG in women with age of 32 - 45 years (14.4%), women without history of pelvic inflammatory disease (11.1%) compared to women with pelvic inflammatory disease (8.9%) and infertile women with distal blocked tube (28.3%). The study concluded there was high prevalence of anti-Chlamydia trachomatis IgG among women with blocked Fallopian tube compared to pregnant women and strong association between anti Chlamydia trachomatis IgG and tubal blockage.
