Abstract:
Introduction; Hyperglycemic state in women affected by gestational diabetes
mellitus leads to change in structure and functions in endothelial cells which
promote the hypercoagulable status and increase the consumption of
antithrombin III in the cord blood of the newborn. Materials and Methods; An
analytical cross sectional study conducted at Sudan University of Science and
Technology in Khartoum from March 2018 to January 2019; 30 newborn’s
cord blood samples collected after delivery from women clinically diagnosed by
gestational diabetes mellitus and 30 newborn’s cord blood samples collected
after delivery from women with normal pregnancy as control group recruited in
this study. Five ml Citrated Cord blood samples ( 3.8 % Tri-sodium Citrate)
were collected from Saad-Aboulela University Hospital, Alsaaha Specialized
Hospital and Al-Qma Specialized Hospital. Antithrombin III level was
measured by using automated Mindray, and then Data analyzed by SPSS
version 20, and expressed as means ± SD, tables and figures Results; The mean
and standard deviation of antithrombin III level in newborn’s cord blood from
women with gestational diabetes was 19.43 ± 6.62 mg / dl , while the mean ±
standard deviation of antithrombin III level in newborn’s cord blood from
women with normal pregnancy was 24.43 ± 6.28 mg / dl. A significant
decreased of antithrombin III level in cord blood from women with gestational
diabetes compared with antithrombin III level in cord blood from women with
normal pregnancy (P. value = 0.005). In addition, there was a significant
decreased of antithrombin III level in cord blood from pregnant women with
gestational diabetic and fasting blood glucose level > 100 mg/dl in compare
with antithrombin III level in cord blood from pregnant women with gestational
diabetic and fasting blood glucose < 100 mg/dl. In contrast, there was no
correlation between antithrombin III level and both gestational weeks and
weight of newborn. Conclusions; There was significant decreased in level of
antithrombin III in newborn’s cord blood from women with gestational diabetes
more than level of antithrombin III in newborn’s cord blood from women with
normal pregnancy. Additionally, antithrombin III level in newborn’s cord blood
of pregnant women gestational diabetes affected by blood glucose level but, it
did not affect by both gestational weeks and weight of baby.
