Association and Variation of Hematological Parameters among Sudanese Patients with Rheumatoid Arthritis in Khartoum State 2018

Abstract

This was an analytic case control study conducted in Khartoum state during period from May to July 2018 to estimate hematological parameters among Sudanese patients with rheumatoid arthritis, The study population was selected as 50 patients and 50 normal individual as control group, Also the study group classified according to their treatment types into 3 different groups whom take steroids treatment (52%), non steroids treatment (8%) and combined drugs (40%). The study was reflect significant increase in mean of TWBCs (mean of case 6.7±2.1 and control mean 5.1± 1.2) with P .000, significant Decrease Hb level (mean of case 11.4 ±1.3 and control mean 13.3 ± 1.8) with P .000, significant Decrease PCV (mean of case 36.3 ±5.0 and control mean 40.9 ± 4.5) with P .000, significant Decrease MCV (mean of case 81.9 ± 8.1 and control mean 92.7 ± 7.3) with P .000, significant Decrease MCH mean of case 25.7 ± 2.6 and control mean 29.7 ± 2.7) with P .000, and significant increase platelets count (mean of case 275 ±75 and control mean 243 ± 58) with P .020, in compare between case and control and no significance on mean of TRBCs (mean of case 4.42 ± 0.47 and control mean 4.45 ± 0.49) with P .707, MCHC (mean of case 31.6 ±3.1 and control mean 31.7 ± 2.3) P .755, also Rticulocyte count mean of case 0.58 ± 0.77 and control mean 0.40 ± 0.38) with P .150. the comparison between types of treatment and hematological parameter show there was significant increase on TWBCs in patient who take steroid ( 6.4± 1.9) an d combined drugs (7.5± 2.5) (P .048), significant decrease on PCV in patient who take steroid drugs (38.3± 5.2) (P .012), significant decrease on MCV in patient who take combined drugs (78.3± 8.0) (P .032), significant decrease on MCHC in patient who take steroid drugs (35.5 ± 2.9) (P .024), there was no significance difference on TRBCs (P .286), Hb level (P.v .269), MCH (P .777), platelets count (P .382) and Rticulocyte count (P .291) in comparison with treatment types. Also study reflex no significance difference between CBC figures (TWBCs P .368, Hb P .898, TRBCs P .787, MCV P .998, MCH P .787, MCHC P .783, PCV P .768, platelets count P .750 and Reticulocyte count P .332).