Assessment of Serum High Sensitivity C-Reactive Protein, Lipid Profile and Magnesium among Sudanese Patients with H. Pylori Infection .( In Khartoum State )

Abstract

Background and Aim : Helicobacter pylori (H.pylori) colonize the human gastric and duodenal mucosa, and the infection may cause peptic ulcers and gastritis. The aim of the study was to assess the level of serum concentration of HsCRP ,lipid profile and Magnesium of gastritis Helicobacter pylori-Infected patients with those of gastritis H.pylori negative. Materials and Methods: This was cross sectional comparative study. The study was conducted in 40 gastritis H.pylori-infected patients and 40 matched gastritis H.pylori negative as control. Stool Antigen H.pylori test was used to determine H.pylori, and BS200 was employed to analyze total cholesterol ,LDL-C,HDL-C and ICHROMA 11 was employed to analyze Hs CRP and biosystem350 spectrophotometer to determinde Magnesium concentrations. Results: Compared to the control subjects, there were significant increase in meams serum level of Hs.CRP, total cholesterol, and LDL-C, P value less than 0.05; for Hs.CRP mean patient vs control (8.5 ±2.1mg/l vs 4.60±2.20mg/l) (p=0.000), for total cholesterol mean patient vs control (150 ±38mg/dl vs 106±27.7mg/dL) (p=0.026), for LDL-C mean patient vs control (70.5 ± 20.1mg/dl vs 54.5±12.7mg/dL) (p=0.006) , there were insignificant decrease in mean of serum HDL-C and magnesium Level concentration, P. value more than 0.05, for HDL-C mean patient vs control (41.4 ±21.3 mg/dL vs 46.1±13.9 mg/dL) (p=0.990), for Magnesium mean patient vs control was (1.9 ± 0.2mg/dL vs 2.00±0.20mg/L) (p= 0.58). Conclusion: Sudanese patient with H. pylori infection had increased level of serum Hs CRP, Total Cholesterol and LDL-C level, and had decreased level of serum HDL-C and magnesium.