D-dimer, PT and APTT levels among Renal Transplant Patients in Sudan

Abstract

Background: Kidney Transplantation is acknowledged as a major advance of modern medicine which provides high-quality life years to patients with ESRD. Microvascular thrombosis and fibrinolytic disorders have been recognized as main cause of allograft rejection in renal transplanted patients, but the pathway through which it occurs has not been clarified yet. Aim: To determine D-dimer, PT and APTT levels among pre and post renal transplant patients in Sudan. Materials and Methods: A descriptive comparative cross sectional study obtained at Sudan University of Science and Technology in period from February to May 2017, the practical worked is performed in the Laboratory of Sharg Alnile Hospital in Khartoum state. Fifty patients of pre renal transplant on dialysis as control and 50 patients of post renal transplant from nephrology unit were enrolled in this study. Their age ranged between 18-70 years. Thirty nine (78%) of them were males and 11 (22%) were females. About 4.5 ml of citrated blood was collected from each patient for, D-dimer, PT and APTT performance and the data was analyzed by SPSS. Results and Conclusions: The study observed that, significant differences of D-dimer levels between control group and patients group (P .value< 0.05), while there were no significant differences between PT and APTT in control group and patients group (P. value> 0.05). The study concluded that, the renal transplantation can correct D-dimer elevation in patients of CKD.