Effect of Cigarette Smoking on Aminotransferase Enzymes Activities and Albumin Level among Sudanese Male Smokers

Abstract

Cigarette smoking has many serious effects on human body and influences many organs such as liver, and it causes hepatotoxicity. This study aimed to determine the effect of cigarettes smoking on Alanine aminotransferase (ALT), Aspartate aminotransferase (AST) activities and Albumin level in Sudanese cigarette smokers. A cross sectional study was conducted during the period from October 2016 to March 2017. A total of 70 cigarette smokers, and 30 non- smokers (as control group) participants were include. A structured questionnaire was designed to obtain demographic and clinical data. Venous blood samples were collected from all participants in heparin containers, assessment of AST, ALT activity and albumin levels done using semi-automated biochemical system international analyzer. The levels of albumin, ALT and AST for smokers and non smokers were (4.03±0.15g/dl, 17.94 Iu/L and 23.24±11.33 IU/L, 4.01±0.65 g/dl, 17.47±8.48 IU/L and 26.10±8.34 IU/dl), respectively. The results showed that insignificant difference in AST and ALT activity and Albumin levels in cigarette smokers compared to non- smokers was found, the level of AST was slightly reduced in a smoker compared to a non-smoker by about 10%. There was significan decrease in the level of albumin in a smoker who used more than 10 cig/day than who used 2-10 cig/day. This study concluded that, cigarette smoking has mild effect on liver function test.