Assessment of Plasma Total Cholesterol, High Density Lipoprotein and Low Density Lipoprotein Levels among Metabolic Syndrome Patients in Khartoum State

Abstract

Metabolic Syndrome is a serious medical condition with increase incidence of multiple cancers risk , has effects on the life quality and it is a problem found all over the world including Sudan and it is fatal unless controlled and treated properly. This is comparative cross sectional study was conducted to assess plasma cholesterol, high density lipoprotein and low density lipoprotein levels in patients with metabolic syndrome. Hundred blood samples (50 controls and 50 cases, ages and genders were matched between two groups) were collected during period from August to September 2018, selected randomly from Zenam Medical Center and Samir Medical Center in Khartoum state, and 50 apparently healthy individuals serves as control group. Enzymatic methods were used to estimate serum T. cholesterol, HDL-C and LDL-C levels, and Spectrophotometer (semi automation instrument), and results were analyzed using statistical package for social science (SPSS version 20) computer program. The study results showed that, increased Mean of Body Mass Index ,Waist Circumference , T. cholesterol , LDL-C and decreased in HDL-C in case versus control group. (30.2 ± 7.0 versus 22.7± 1.2 Kg/m2), (102.2 ± 15.2 versus 79.2 ± 2.7 cm), (152.6 ± 23 versus 127.2 ±9.5 mg/dl), (47.6 ± 6.7 versus 73 ± 6.8 mg/dl), (78 ± 9.6 versus 42.6 ± 6.9 mg/dl ) respectively. Also the findings of This study showed that , there was weak negative correlation between T. cholesterol and and duration of disease (r= -0.364, P-value = 0.009), while there were no correlation between (HDL-C and LDL-C) and duration of disease, (r= -0.022, P-value = 0.881), (r= -0. 048, P-value = 0.741) respectively. And no correlations between (T. cholesterol, HDL-C and LDL-C) and age . (r= -0.151, P-value = 0.294), (r= -0.025, P-value = 0.864), (r= -0.258, P-value = 0.07) respectively. Also there were no correlations between (T. cholesterol, HDL-C and LDL-C) and Body Mass Index ,Waist Circumference (r=0.098, P-value =0.50), (r= -0.089, P-value = 0.537), (r= -0.082, P-value = 0.573), (r=0.145, P-value =0.316), (r=-0.136, P-value =0.347), (r=-0.027, P-value =0.852) respectively. It is concluded that: the plasma T. cholesterol and LDL-C are increased while HDL-C is decreased in metabolic syndrome patients .