Frequency of Herpes simplex Virus Type-2 IgM and IgG among Pregnant Women in Wad Madani Maternity Hospitals (Sudan)

Abstract

This was descriptive cross-sectional study conducted at Wad-Madani Maternity Hospital and Dr.AltiganiSedeeg Fertility Center AL-Gezira state during the period from April to August 2018. This study aimed to detect the frequency of HSV-2 IgG and IgM among pregnant women by using ELISA technique and to evaluate possible association between HSV and age, trimester, and history of abortion. Blood sample was collected from each participant and then serum was obtained. Ninety-two pregnant women were included in the study.Out of them 46 (50%) their age from 15-24 years, 35(38.04%) from 25-34years and 11(11.96%) from 35-44 years. Considering the gestation trimester of participants 75(81.5%) were in first trimester, 17(18.5%) were in second trimester. Pregnant women with history of abortion 43(46.7%) and pregnant women without history of abortion 49(53.3%). The sera were examined for the presence of IgM/IgG using (ELISA). The study showed that the frequency of HSV-2 IgMamong pregnant women was (38%) while IgG was (97.8%). Higher frequency showed in pregnant women with age group 15-24 year for IgM13(37.14%)/IgG45(50%). The seropositivity of HSV-2 IgM among pregnent women in first trimester were 26(34.6%) for IgM 75(100%) for IgG. Pregnant women with history of abortion19(44.2%)for IgM and43(100%)for IgG while 16(32.6%)for IgM and 47(96%)for IgG were pregnant women without history of abortion.In this study, there is no association between HSV-2 (IgM and IgG) seropositivity with age, trimester & a history of abortion. Further studies with larger sample size are required to confirm these results.