Measurement Of CBCAnd Prothrombin Time Among Patients With Gastrointestinal Bleeding In Khartoum State

Abstract

The study descriptive (Cross sectional) aimed to measurement the mean level of complete blood count parameter and prothrombin time (PT) In patients with gastrointestinal bleeding (GIB).The study conducted through the period from June to Sep 2018, in Mohammed Salih Idres Center for gastrointestinal bleeding in Ibn Sina Hospital in Khartoum state. The study population compromise two groups of adults in different age for both sex (66 males and 24 females) in age range from(18-70 years old). 90 subject were recruited for this study, 60 patients with acute gastrointestinal bleeding with first time bleeding and 30 healthy volunteers as control group. The data was collected using laboratory investigation to obtain CBC result and prothrombin time test. Also data collected using questionnaire. Five of ml venous bloods were collected from all participants 2.5ml was added to trisodium citrate anticoagulant and 2.5ml was added in EDTA anticoagulant containers. The data analyzed by SPSS version 16.The data show that about 66% of GIB patients were males and 24% were female. The distribution of GIB patients according to age show that the mean age were 44 years .The clinical manifestation of patients distributed as 41% with hematemesis, 34.4% with melena, 18.9% with bilharzia and 13.3% with bloody stool. The present study revealed significantly (P.V= ≤ 0.000) lower Hb, RBC, PCV, MCV, MCH, PLT values in GIB patients compared with normal control (Table 3.1). The WBC and PT values were significally (P.V=≤0.001) and (P.V=≤0.000) higher in GIB patients compared to the normal control respectively, while no significant change in MCHC among GIB patients. The study showed that the gastrointestinal bleeding patients may be at risk of anemia, hypoxia, thrombocytopenia and hypercoagulable state. Also the study proved the GIB have the quite similar effect in patients regardless of gender and age although the males were more frequently affected by disease.