Serum 25-Hydroxy Vitamin D Levels Among Adults Patients with Acne Vulgaris in khartoum state

Abstract

Background :Acne vulgaris is a common chronic inflammatory disease of the skin. Vitamin D plays an important role in the immune system, and its deficiency has been implicated in various skin diseases, including atopic dermatitis and psoriasis. Objectives: The aim of this study wasto evaluate the serum 25 hydoxy vitamin D levels among patients with acne vulgaris . Methods :This study was a cross sectional case control hospital base study performed in Khartoum state at military Hospital department of Dermatology and venerology, 60 samples were collected from patients suffering from acne vulgaris. Acne severity was classified according to Global Acne Grading System (GAGS). In addition 60 samples were collected from healthy individuals sex and age matched as control group .The levels of serum 25 hydoxyvitamin D was measured in each group by immunoassay analyzer cobas-e-411-2ed generation platform of Electrochemiluminescence binding assay (ECLIA). Results :The study showed significant decrease in the 25 hydoxy vitamin D concentrations in acne vulgaris patients when compared with the control group (13.7 ± 5.07 ng/mL vs 24.8 ± 11.0 ng/mL) (p = 0.00) .The study observed significant decreased in serum 25 hydoxy vitamin D levels with increaseacne grading, mild 11 patients (18.3%) (16.8 ± 3.42 ng/mL), moderate 37 (61.7%) (13.9 ± 4.33 ng/mL) and severe 12 (20%) (10.4 ± 1.64 ng/mL) (p = 0.01).The present study showed no correlation between vitamin D levels (ng/ml) and age (years), BMI (kg/m²) in study group. On the other hand significant correlation was noted between serum vitamin D level (ng/ml) and expoture to sunlight in acne vulgaris patients (r = 0.36, p = 0.04). Conclusion: This study revealed that serum vitamin D levels are significantly decreased in patients with acne vulgaris .