Abstract:
Osteoporosis is a systemic skeletal disease characterized by low bone mineral density (BMD) and
microarchitecture deterioration of the bone, leading to increased fragility and a high risk of
fracture. It is a silent disease until fractures occur, which causes important secondary health
problems and even death. Osteoporosis is the most common bone disease in humans, representing
a major public health problem. The aim of this study was determine of Parathyroid hormone,
calcium and phosphorus among women with osteoporosis in compare with control group
This is case control study conducted in Khartoum state in period from February to December 2018,
this study includes 90 Sudanese women 50 of them are diagnosed to have osteoporosis and 40 are
healthy controls for comparison. Three ml of venous blood obtained from each participant and
placed in heparin containers for estimation of calcium, phosphorus and parathyroid hormone, the
samples were centrifuged to obtain plasma, then plasma transferred to Eppendorf tube and kept at
-30 until time of analysis. The calcium and phosphorus were analyzed by spectrophotometer using
reagent kits supplied by BioSystem company and parathyroid hormone was analyzed by ELISA.
The results show significant decrease in mean level of calcium in osteoporotic patients when
compared to control group (p. value: 0.000), while parathyroid significantly increased in
osteoporotic women when compared to control group (p.value 0.001) and insignificant differences
in phosphorus and BMI mean levels between case and control group (p.value : 0.246 and 0.068
respectively).
Also results revealed a significant positive correlation between parathyroid hormone and
phosphorus (r = 0.296, p. value 0.037), and no correlation between parathyroid hormone and
calcium (r = 0.111 p. value 0.441), and no correlation between calcium and phosphorus (r = -0.071
p.value 0.623).
The study concluded that, osteoporotic patients had decreased calcium level and increased PTH
level when compared to healthy control group, while there was no difference in phosphorus and
BMI between case and control and there was significant positive correlation between PTH and
phosphorus in osteoporotic women.
