Evaluation of 25-OH Vitamin D, Total Calcium and Phosphorus Levels in Post-Menopausal Sudanese Women with Osteoporosis تقو

Abstract

Osteoporosis is disease characterized by low bone mass and microarchitectural deterioration of bone tissue leading to enhanced bone fragility and a consequent increase in fracture incidence. The osteoporosis is becoming public health problem in Sudan and neighboring countries and worldwide. As the environmental risk factors for osteoporosis in women are similar, the study aim to evaluate 25-OH vitamin D, total calcium and phosphorus levels among Sudanese post-menopausal osteoporotic patients compared to non-osteoporotic healthy women as controls. A case control study was conducted in Khartoum state from March to October (2018), total of 50 osteoporotic patients and 50 non-osteoporotic healthy controls matched for sex and presence of other diseases were enrolled in this study. Serum 25-OH Vitamin D were measured using ELISA technique, while total calcium measured via methylthymol blue method and phosphorus were measured using molybdate method. Serum 25-OH Vitamin D level and calcium level were significantly decreased while serum phosphorus level was significantly increased (p<0.001) in case group compared with control healthy women. We also found insignificant correlation between 25-OH vitamin D level and calcium, phosphorus levels in osteoporotic women and insignificant correlation between serum calcium and phosphorus level. The data of the study suggest that Sudanese postmenopausal osteoporotic women had lower 25-OH vitamin D and calcium level and higher phosphorus level. Meanwhile, no associations were observed between age and 25-OH vitamin D and study variables.