Effect of Acidosis on Uropathogenic Bacterial Growth among Diabetic ketoacidosis Patients in East Nile Locality, Khartoum state

Abstract

Diabetes is a group of metabolic disease characterized by hyperglycemia resulting from defect in insulin secretion, insulin action or both. Diabetic ketoacidosis ( DKA) is a type of diabetes complication lead to coma and death, the main characteristic of Diabetic ketoacidosis ( DKA) are: hyperglycemia and ketoacidosis. Urinary tract infection is the most type of infection in diabetic patients especially in females more than males. This study aimed to detect bacterial growth in diabetes ketoacidosis urine and to compare the percentage of growth between Diabetic ketoacidosis patients and Diabetes patients without Ketoacidosis. Out of 50 cases of diabetic ketoacidosis 20 males ( 40 % ) and 30 females ( 60 % ), the age group between 23-33 years have high occurrence of diabetic ketoacidosis 24% .The duration period of onset diabetic between1 -5 years was 41.9 % and reflect high incidence rate of diabetic in the last five years. 14 ( 28%) and 36( 72%) were symptomatic and asymptomatic of UTI respectively . 74% of diabetes ketoacidosis having urine pH 5 while those with pH 6 were 26%. The present results show inhibition action of acidosis against urine pathogens among diabetic ketoacidosis patients in East Nile province only 2% of bacterial growth while 98% was inhibited. The only bacteria in acidic urine in this study was Klebseilla pneumoniae may be due to presence of large capsule. Among 25 diabetes patients non- ketoacidosis 13 ( 52 % ) were females and 12 ( 48 %) were males with age group between 36- 70 years old and blood glucose level between 170 – 295 mg \dl , four microorganisms isolates were detected in the urine samples of non- ketoacidosis 4 ( 16%) two Esherichia coli ( 50%) , one Klebseilla pneumoniae ( 25%) and one Candidia spp ( 25 %)