Abstract:
Background: Gestational diabetes mellitus (GDM) is the most
common medical complication of pregnancy. It is associated with
maternal and neonatal adverse outcomes. Fibrinogen level has been the
intensive study in latest years. In addition, there is an association
mentioned in previous records between fibrinogen level and newborn
metabolic diseases, liver disorders and some cancers.
Objectives: To evaluate and estimate fibrinogen level in newborn cord
blood of gestational diabetes mellitus mothers from February to August
2018, and to compare with fibrinogen level of newborn cord blood of
healthy pregnancy. Moreover, to correlate fibrinogen levels according to
the gestational weeks and weight of newborns.
Materials and Methods: A case control study was conducted on 60
newborns from 30 mothers with GDM and 30 healthy mothers after
ethical consent and hospital approval. Citrate cord blood samples were performed for fibrinogen estimation.
Results: There were statistically significant increase of fibrinogen level
(P.value=0.026) among newborns with GDM mothers
(257.66±32.61mg/dl) compared with control group (236.77±37.93mg/dl).
And there was significant increase in fibrinogen level in newborns with
mothers FBG<100 mg/dl (249.44 mg/dl) compared with mothers
FBG>100mg/dl (231.33 mg /dl) (P. value=0.031). No correlation
between mentioned level and gestational weeks (P. value=0.414) and also
the weight of newborns (P. value=0.401).
Conclusions: There were significant increase of fibrinogen level among
newborns with GDM mothers and no correlation between mentioned
level and gestational weeks and also the weight of newborns.Increased fibrinogen level may contribute to the development of
thrombotic risk.
