Abstract:
Background: Combined oral contraceptive are medication administrated by
mouth that prevent pregnancy primarily by inhibiting ovulation .long term
using of c0mbined oral contraceptive lead to increase lipid profile, body mass
index and increase risk of hypertension and cardiovascular diseases, so this
study aim to evaluate lipid profile among women using combined oral
contraceptive more than one year in Elgazera state.
Materials and methods: this study was included (100) women, (50) women
using combined oral contraceptive and (50) women non using combined oral
contraceptive at same age, blood specimen was collected from both groups and
total plasma cholesterol, high density lipoprotein cholesterol and low density
lipoprotein cholesterol were analyzed by using full automated analyzer(
DIRUI .CS.T 240).
Results: the result revealed that there was significant increase of the means of
total plasma cholesterol in combined oral contraceptive group (182± 24.8
mg/dL) when compared with control group (140.2± 24.4 mg/dL ), p value
(0.00),there was insignificant decrease of the means of serum HDL-C in
combined oral contraceptive group (51.9± 11.7 mg/dL) compared with control
group (54.1±9.4 mg/dL), p value ( 0.289), and insignificant increase of the
means of LDL-C in combined oral contraceptive (96.7± 24.4 mg/dL)
compared with control group ( 91.8± 15.8 mg/dL), p value (0.230), also there
was significant increase of the mean of body mass index in combined oral
contraceptive group (31.5± 2.8 mg/dL) compared with control group
(28.1±2.5 mg/dL) , with p value (0.00). There were significant positive
correlations between total cholesterol and (age, BMI, and duration of using
contraceptive).
Conclusion: this study concludes that, women received combined oral
contraceptive had higher level of plasma total cholesterol , plasma LDL-C, and
lower level of plasma HDL-C, and significantly positive correlations between
plasma total cholesterol and (age, body mass index and duration among women
using combined oral contraceptive).
