Evaluation of Estradiol Hormone Level in Healthy Obese Subjects in Khartoum State

Abstract

Background: Obesity is associated with abnormal sex steroids concentrations and it is related to the degree of obesity, this study was carried out to evaluate serum level of estradiol hormone in obese subjects. Material and methods: Fifty samples were collected from obese and overweight (male and female) in period between August to November 2017, chosen randomly in Khartoum State, and 50 apparently healthy individuals with normal BMI as control group, to assess the effect of obesity on estradiol hormone level. Estimation of serum estradiol level was done by using TOSOH, and results were analyzed using (SPSS) computer program. Result: The result of this study showed that the means concentration of estradiol hormone in obese subject was significantly increased compared to control (Mean ± SD for cases versus control). (146.3±108.6 versus 63.4±52.8, pg/ml , P. value=0.00), it showed that the means concentration of estradiol in obese male was significantly increased in compared to control male (68.2 ±39.2 versus 36.2 ±13.2,pg/ml P.value =0.01), the means concentration of estradiol in obese female was significantly increased in compared to control (: 185.2± 111.7versus 81.6 ± 61.2, P.value =0.00). Also showed that mean concentration of estradiol in obese class 1 was significantly increased in compared to control (129.5±116.6versus 61.7±53.6, pg/ml, P. value=0.001), Gender distribution among study group 40% was male and 60% was female. There was Strong positive correlation between BMI and estradiol in obese male (r=0.7, p=0.03). Conclusion: It is concluded that: the serum level of estradiol hormone increases in both obese male and female.