C-reactive Protein, Serum Magnesium and Lipid Profile Among Obese and Overweight Subjects in Khartoum State

Abstract

Background : Obesity considered a “disease state” due to the changes it causes on the body as increasing the risk for a large number of additional diseases. type two diabetes, dyslipidemia, stroke and it associated with Inflammatory processes that have important roles in the etiology of cardiovascular diseases and this study aimed to evaluate C-reactive protein, lipid profile and serum magnesium in obese and overweight subjects Materials and Methods: Ninety Sudanese individual were enrolled in this study, classified into 30 obese,30 overweight and 30 normal weight as control match group. Serum CRP was measured by using immunoturbidymetric method, lipid profile and serum magnesium were estimated by chemical detection method using colorimeter. Results: The study showed that obesity was more common in female(62.2%) than male (37.7%) with ratio 1.00:2.00 and mean of age (28.0±5.00)years ,also the results showed that CRP and lipid profile (TC ,TG ,LDL-C) were significantly increased among obese and overweight versus control mean ± SD values of CRP (mg/L )to be ( 68.0± 50.0),(14.4±12.0) versus(4.40±3.00) with p value =0.000 serum total Cholesterol (mg/dL) to be (207±49.0), (163 ±16.0) versus (144 ±13.0) with p value =0.000, serum triglyceride (mg/dL) to be(122 ± 35.0), (97.0 ±23.0) versus (74.0 ±19.0) with p value =0.000, serum HDL-C (mg/dL) to be (39.0±3.10), (44.0± 5.00) and (51.0± 10.0) with p value =0.000, S-LDL-C (mg/dl) to be (104± 37.2 ), (75.9 ± 24.0) versus (61.0 ± 16.4) with p value =0.000, stating that the differences were statistically significant. result also showed significantly decreased in HDL-C and magnesium in both obese and overweight versus control group , HDL-C (mg/dL) to be (39.0±3.10), (44.0± 5.20) and (51.0± 10.0) with p value =0.000 serum magnesium (mg/dL) to be (1.40±0.14 ), (1.60±0.20) versus (1.90±0.21) with p value =0.000 respectively. Conclusion: The study concludes that obesity is more common in female than male and serum CRP, Total serum cholesterol S-triglyceride , S-LDL-C are higher in both obese and overweight and serum magnesium ,S-HDL-C are low in both obese and overweight subject.