Abstract:
Diabetic retinopathy (DR) is a very common complication of diabetes
mellitus, leading to visual deficits and blindness around the world.
A case control study conducted to measure serum lipid profile in diabetic
patients with retinopathy. 50 samples were collected from diabetic
patients with retinopathy in period between July to November 2017,
chosen randomly from Alfaisal eye center, and 25 diabetic patients
without retinopathy as control.
Sherwood colorimeter 260 was used for measurement lipid profile (total
cholesterol, triglycerides, LDL-c and HDL-c) and results were analyzed
using statistical of package social science (SPSS) computer program.
This study showed that, in retinopathy total cholesterol and LDL-c were
significantly increased when compared to a control group (mean+ SD:
174.5 +36.8 mg/dl versus 146.6+27.0mg/dl p.value = 0.00), (mean+ SD:
105.6+33.8 mg/dl versus 81.2+21.5 mg/dl p.value = 0.00) respectively.
There were insignificant difference for HDL-C and triglycerides
compared with control group (mean+ SD: 36.4 +8.4mg/dl versus
33.6+5.7 mg/dl, p.value =0.146), (mean+SD: 120.8+61.3 mg/dl
versus96.4+38.4mg/dl, p.value =0.074) respectively.
The result showed, there were no correlation between Cholesterol,
Triglycerides, LDL and duration of the disease (r=0.058, p-value=0.622),
(r=-0.010, p-value=0.933), (r=0.045, p-value=0.703) respectively and
there was insignificant weak negative correlation between HDL level and
duration of disease (r=-0.235, p-value=0.043). Also there were no
correlations between cholesterol, triglycerides, LDL and age of diabetic
retinopathy (r=0.077, p-value=0.514), (r=0.035, p-value=0.768),
(r=0.081, p-value=0.489) respectively and there was significant weak
negative correlation between HDL level and age of diabetic patients with
retinopathy (r=-0.255, p-value=0.027). The study concluded that, there
was significant increase in cholesterol and LDL-c in diabetic retinopathy.
