Abstract:
This is a case control study carried out in Khartoum state in Antalya Medical Center during the period from August 2015 to April 2016. One hundred patients were enrolled, 50 with hyperthyroidism and 50 with hypothyroidism; in addition, 50 healthy volunteers were included as a control group. Forty six of patients with hyperthyroidism and 40 of patients with hypothyroidism were females, while 4 of patients with hyperthyroidism and 10 of those with hypothyroidism were males. Thirty of control group were females, while 20 of control group were males. Mean of patients age between (34±12) year , while mean of control age between (35±17) year.
Three ml of venous blood was withdrawn from each participant,then placed in blood tube containing EDTA which act as anticoagulant.
Complete blood count was performed using an automated cell counter (Sysmex KX-21N). The results were analyzed by statistical package of social science (SPSS). The result showed a significant decrease in hemoglobin level, hematocrit, mean corpuscular volume and mean cell hemoglobin in patient with hyperthyroidism compared to control group (P. value<0.05). Hemoglobin level, hematocrit,mean corpuscular volume and mean cell hemoglobin and mean cell hemoglobin concentration showed significant decrease in hypothyroid patient when compared with control group (P. value< 0.05).
No significant difference was found in mean total leukocyte counts when compared in the study groups (P. value>0.05).Neutrophilia have been observed in hypothyroidism patients (P. value <.05).
Platelet count showed no significant difference in hyperthyroidism and hypothyroidism groups when compared with control group (P. value>0.05). There was no statistically significant correlation between red cell parameters, total leukocyte counts, and platelet count of hyper -and hypothyroidism patients and age (P. value>0.05). Also no statistically significant correlation was found red cell parameters, total leukocyte counts, and platelet count of hyper- and hypothyroidism patients and T4 (P. value>.05).
There was statistically significant correlation between MCH of hyperthyroidism patients and T3 (P. value <.05), while other red cell parameter, total leukocyte count differential count, and platelet count showed no statistically significant correlation with T3 (P. value>.05).
There was statistically significant correlation between MCV, MCH, and MCHC of hyperthyroidism patients and TSH. Hb, HCT and MCH of hypothyroid patient showed significant correlation with TSH (P. value <.05) while total leukocyte count, differential count and platelet count showed no statistically significant correlation with TSH (P. value>.05).
In conclusion,hyperthyroidism and hypothyroidism have negative effective on Hb ,Hct and MCH, while it has no effect on total WBCs count or platelet count.
