Abstract:
The thyroid gland is one of the most important endocrine gland responsible for the secretion of thyroxine (T4) and triiodothyronine (T3) the two major thyroid hormones, are the regulators of growth, development, and basal metabolic rate, and both hormones modulate energy utilization and heat production and facilitate growth as well. Globally, tobacco use is one of the commonest licit substances of abuse and is projected to kill 50% more people than HIV/AIDS by 2015, and to be responsible for 10% of all deaths by 2030. This case control study was done for the estimation of thyroid hormone and C- reactive protein in Sudanese males Tobacco users and its clinical correlation. It was conducted in the United Arab Emirates Sudanese social clubs of the Emirates of Ajman and Dubai, from January 2015 to December 2015. A questionnaire was designed to study person’s age, tobacco using, type of Tobacco, clinical problem such as diabetes and hypertension, after signing the consent form a total of 100 Samples were collected from Sudanese males, age ranged from 22-66 years. The blood draw as a venipuncture in a plain gel separator tube red capped and centrifuge speed was 3000/rbm10 minutes. Serum obtained for the analysis was done in Cobas E411 from Roche for the thyroid hormones, CRP analyzed in Cobas Integra 4000 plus. All the results were filled out in the data collection sheet.
Tobacco users were 51 persons (51%) which (smokers and tobacco chewers) and non-tobacco users 49 (49%). These tobacco users there further divided into smokers only 19 persons (37%), chewing tobacco only 14 (27%) and individuals who were both chewers and smokers 18 persons (36%).The study concluded that there is a tobacco effect on the thyroid hormones level especially reduction in T4 while other findings although reflective for tobacco effect compared to normal, were markedly not significant except the reduction ofT4.The C-reactive protein was significant among chewers and both chewer and smokers group with p= 0.0001.As opposed to other studies, we found CRP to be reduced among chewers and chewers and smokers group, with its reduction may indicate that chewing may halt inflammatory response.
