Effect of Haemodialysis on Plasma levels of Phosphate, Urate and creatinine in Patients with Chronic Renal Failure

Abstract

Across- sectional study was conducted during the period from March to June 2011 to evaluate the plasma levels of phosphate, urate and creatinine before and after dialysis among Sudanese patients with chronic renal failure in Khartoum state selected from Dr.salma center for renal diseases. Sixty patients on haemodialysis were selected for this study. Two blood samples were collected from each patient before and after dialysis in heparin containers, plasma phosphate, urate and creatinine were measured using a spectrophotometer. The means of the plasma levels of phosphate, urate and creatinine after dialysis were significantly reduced (p=0.00) for each. The study showed no correlation between the plasma levels of phosphate and creatinine pre dialysis and there was a weak positive correlation between the plasma level of phosphate pre dialysis and the duration of chronic renal failure. Also the study showed a weak positive correlation between the plasma levels of urate and creatinine pre dialysis, and there was no correlation between the plasma levels of urate pre dialysis and the duration of chronic renal failure. In the present study the majority of patients on haemodialysis have hypertension (40%), diabetes mellitus (3.3%), diabetes and hypertension (6.7%) ,gout(20%), renal stone (13.3% ), and (16.7%) have other etiology.‫‪From the result of this study, it's concluded that haemodialysis‬‬ ‫.‪significantly reduced the level of phosphate, urate and creatinine‬‬