Abstract:
Background: Gall stones formation is a multifactorial process and many
studies have shown that insulin resistance is one of the associated
factors; previous studies have been established to link between insulin
resistance and gall stones disease. This study aims to evaluate insulin
resistance index (HOMA-IR) among gall stones patients in Khartoum
state.
Materials and methods: sixty individuals were enrolled in this study
and divided into two groups, thirty patients with gall stones and thirty
apparently healthy individuals as control group. Fasting plasma glucose
and serum insulin were measured using fully automated devices, and
then HOMA-IR was calculated.
Results: results showed that the insulin resistance index (HOMA-IR) is
significantly increased in gall stones patients when compared to control
group p-value =0.001
The study showed insignificant difference in mean concentration of
glucose and insulin resistance index among sex with p -value =0.611 and
0.623 respectively. But the study showed that there is significant increase
in mean concentration of insulin among males with p- value=0.045.
Also the study showed that there were insignificant correlation between
age and HOMA-IR and between BMI and HOMA-IR, but there is strong
positive correlation between HOMA-IR and glucose and insulin with pvalue
=0.000
for
both.
Conclusion:
The data suggested that the risk of gallstone formation
increased in female, obese, postmenopausal women and was associated
with changes in insulin resistance index.
