Assessment of osteoporosis in patients with prostate cancer using bone scintigraphy and computed radiography

Abstract

The development of radiology and medical imaging was much helper in all fields of medicine with new technologies such as DEXA technology, which measures the fragility, hardness and bone mass by measuring the mineral density of bone. DEXA is an important technique for specialists and the general public because the osteoporosis has become an important problem for women over the age of 40 and the elderly of both sexes. Osteoporosis has been the subject of many researches, many devices and different techniques have been developed to measure the most important indicators of bone density and bone mineral content. This study, in an attempt to measure osteoporosis with other available techniques, was used to establish caution in early stages of vulnerability. We assessment of osteoporosis in patients with prostate cancer using bone scintigraphy (Gamma camera) and computed radiography (CR). Before bone scintigraphy (G.C), patients undergo digital X-ray imaging (CR) of the lumbar spine and hip bone, which is the most vulnerable according to previous studies, and also gives accurate readings of any change in density. The images were collected on flash memory (USB) and then re-processed and analysing the image with Interactive Data Language IDL software version 6.1 to measure the grey level variation of images in the lumbar spine and hip bone area. The study was conducted at Radiation Isotopes Canter of Khartoum and Antalya Medical Center in Khartoum State from July 2014 to July 2017. The data was available for 200 patients, 70 abnormal patients with prostate cancer was taken CR and G.C images for hip and spine, and 130 normal patients CR for spine and hip taken as a control group. The results show that: The mean of normal hip CR and normal spine CR were 619.67± 86.39, 598.77 ±73.34, The mean of abnormal hip CR and abnormal spine CR were 2526.43 ± 310.63, 1988.03±592.445, and the mean of abnormal spine Gamma Camera and abnormal hip Gamma camera were 630.67±87.57, 582.57± 87.57 V And by using T.Test Show that there is no significant difference between normal CR and abnormal CR for hip and spine regions. The Linear regression results show rate of change between normal CR and abnormal CR for hip and spine decreasing by rate 0.0596 and 0.0172 for normal versus one unite of abnormal CR. The study show that there is significant difference between normal CR and abnormal G.C for hip and spine regions. And the Linear regression results show rate of change between normal CR and up normal G.C hip was increasing by rate 0.8301 for normal CR versus one unit of abnormal G.C hip, and by rate of 0.6607 for normal CR spine versus one unit of abnormal G.C spine. Also show that there is no significant difference between abnormal CR and abnormal G.C for hip and spine regions. And the Linear regression results show rate of change between abnormal CR and abnormal G.C hip was decreasing by rate 0.0369 for abnormal CR versus one unit of abnormal G.C hip, and increasing by rate of 0.0147 for abnormal CR spine versus one unit of abnormal G.C spine. And the most effected age was 69-74 years, and the effected period of treatment 1-1.8 years, the PSA most effected value 6-7.4 ng/ml and the most frequency of body mass index 25.8-28.8 kg)cm2 .