Determination of ProthrombinTime , Activated Partial Thromboplastin Time and D- Dimer Among Sudanese Patients with Diabetes Mellitus type 2

Abstract

This is analytical case control study carried out in Khartoum state in Almotakamel hospital in Omdurman, and Haematolog Department in algilly laboratory, during the period from December 2016 to August 2017 to evaluate some coagulation parameters in Sudanese patientS with diabetes mellitus type2 .Fifty sex diagnosed diabetes mellitus type 2 patients were enrolled cases and 56 healthy individuals were selected as control groupwith age more than 20 years, 4.8 ml of venous blood was with drown from each patient, placed in tri sodium citrate containerthen centrifuge to get platelet poor plasma (PPP) and that to measure PT , APTT and D dimer the result was analyzed by Statistical Package for Social Sciences SPSS version 20, and expressed as means ,STD,P value. The results obtained from patient’s that the means of prothrombin time, activated partial thromboplastin time within the normal rang but significant increase than the result in control group, in patients group (11.8± 0.9sec) ,(31.8 ± 5.5 sec) respectively , the means of PT , APTT in control group ,(11.4±0.8sec), (28.5±3.3sec) respectively( p.value< 0.05) . The result of D dimer significant increase the mean in case group 0.66±0.18 while the mean in control group 0.49±0.12( p.value< 0.05) . There is no significant d1ifferences in both group of sex (p. value> 0.05). According to the duration of disease and age of patient there was significant increase in D-dimer, PT and APTT (p. value < 0.05).The result of study raised that measurement of D-dimer could be identifying risk group of diabetes mellitus type 2who were likely to develop thrombotic events.