Abstract:
Electrolyte and trace elements disturbances frequently occur
with leukaemia patients that complicate their management and
prolong patients’ hospitalization, due to leukemic processes,
organ infiltration, and cell death or to adverse effects of
cytotoxic drugs. This research work investigated the
interrelationship among different types of leukaemia with
concentration of electrolytes and trace elements in Sudanese
patients attended the Radiation and Isotope Center (KRIC)
Khartoum, Sudan. 201 subjects (79 control participants and 122
were suffering from leukaemia). Patients were divided into four
groups; acute lymphoid leukemia (ALL), acute myeloid
leukaemia (AML), chronic myeloid leukaemia (CML), chronic
lymphoid leukaemia (CLL). Some electrolytes and trace
elements zinc (Zn), copper (Cu), manganese (Mn) and cobalt
(Co). Results obtained showed that a significant decrease in
serum level of Cu (p < 0.001), Mn (p < 0.05) and cobalt (p <
0.05) was observed in all groups. Zinc and calcium showed
lower levels in CLL, CML and ALL (p< 0.05). The results also
showed significantly higher serum level of Zn in AML group
than CML group (p<0.05). Magnesium reported higher level in
CML, AML and ALL (p< 0.01). The concentration of Mg was
significantly lower in CLL (p<0.05) compared to CML, AML
and ALL patients. The concentration of sodium was significantly
lower in CML than the ALL patients (p<0.05). There is no
significant difference between the levels of Na, K and PO4
3- in
leukaemia patients and control. Data revealed positive
correlation between sodium and potassium (p = 0.000), positive
correlation between calcium and phosphorus but not significant (
p = 0.195). It could be concluded that Ca, Cu, Zn, Mn and Co
showed lower level and Mg reported higher level in leukemia
patients.
