Evaluation of Prothrombin Time, INR and Activated Partial Thromboplastin Time among Pulmonary Tuberculosis Patients in Khartoum State

Abstract

This was case control study, conducted in Khartoum state at Aboanga hospital during the period from January to April 2017. The study aimed to evaluate some coagulation parameter (PT,INR andAPTT) in pulmonary tuberculosis patients. Study include 50 active TB patients (cases) and 50 non TB patients (control), all subject were informed verbally about the study and approved for participation. from each participant 1.8ml of venous blood collected in tri sodium citrate anticoagulant container in a ratio of (1:9), centrifuged to prepare platelet poor plasma from which targeted parameter (PT,INR andAPTT) measured using coagulation analyzer (diagondia timer-2 ). Results analyzed by independent T-test and Pearson correlation test by SPSS (version 11.5) computerized program. Demographic data collected through questionnaire showed that most of study participant were males78 % (39/50) rather than females 22%(11/50) ,44%(22/50) were smoker while 56%(28/50) are non-smoker, and Age of participated TB patients distributed from 16-58 years with mean age of 32+/- 11years. Age divided in to three age groups(15-30), (31-45)and (46-60) years. age group of (15-30) years was most frequent48% (24/50), while group of (46-60) years have the least frequency among cases 12% (6/50). The result obtained from patients show that means of PT,APTT and INR are (16second, 46 second and 1.2) respectively, and it was reflect that there is clear significant difference in APTT (p. value 0.000) between cases and control group while there is slight significant difference in PT(p. value 0.053) and INR (p. value 0.052) between them. Results also show that there is no significant difference in measured parameter (PT, INR andAPTT) between smoker and non-smoker(p. values 0.51, 0.55, 0.63) respectively. And same results obtained for sex groups (p. values 0.23, 0.21, 0.56) respectively. Finally the result show presence of weak positive correlation between (PT/APTT) and (INR/APTT) P and r values are 0.035/ 0.300 and 0.041/ 0.291 respectively.