Abstract:
The current study was conducted to assess the pharmacotoxic
effects of repeated administration of Ivermectin (Intermectin 1%)
injection formulation in male donkeys. The various haematological,
biochemical parameters and histopathological changes were noted.
Two groups each of six of male donkeys were utilized in the current
investigation. Following fasting for 48 hours, Ivermectin was
administered subcutaneously at the neck region either at the
recommended dose level 200 g/kg (T1) or at 5 times the
recommended dose. 1000 g/kg (T2) body weight for seven
successive days to one of the groups, respectively. Ivermectin was
found to pose risks of renal and hepato-toxicity in donkeys, since
the biochemical parameters of liver function (aspartate
aminotransferase "AST" activity, alanine aminotransferase activity
"ALT") and kidney function (urea concentration) were severely
affected. Changes in biochemical parameters were more intense in
donkeys from group T2 than those reported in group T1. Four
animals out of six died following treatment in group T2. The level
of ALT, AST, and urea were significantly elevated in donkeys from
group T2 when compared to the pretreatment values. Post-mortem
and histopathological examination ensured biochemical alterations
of liver and kidneys. Likewise, some haematological indices:
erythrocyte count, leukocyte count, haemoglobin concentration and
PCV, were also influenced. In conclusion the repeated
administration of Ivermectin injection formulation at five times the
recommended dose is fatal to donkeys.
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