The Efficacy of Sulphadimidine, Gentamicin, Oxytetracycline and their Combinations in Nubian Goats Exprimentally Infected with Trypanosoma evansi

Abstract

The objective of the present study was to evaluate the efficacy of sulphadimidine, gentamicin, oxytetracycline and their combinations in Nubian goats experimentally infected with T.evansi. Eight groups were used in this study. All experimental groups were infected with T.evansi except group (1) uninfected and untreated. While group (2) was infected and untreated, groups (3, 4, and 5) were treated with single i/m dose of sulphadimidine (200mg/kg), gentamicin (4mg/kg) and oxytetracycline (20mg/kg) respectively. Groups (6, 7 and 8) were each treated with single i/m dose of combination of sulphadimidine (200mg/kg) + gentamicin (4mg/kg), sulphadimidine (200mg/kg) + oxytetracycline (20mg/kg) and gentamicin (4mg/kg) + oxytetracycline (20mg/kg) respectively. No clinical signs were shown on goats of groups (3-8) post treatment. No significant changes were observed for the temperature, respiratory rate, pulse rate and heart rate in groups (2-8) and for the RBCs count, PCV, haemoglobin concentration and the red blood cells indices and WBCs count, eosinophils, basophils and serum total proteins concentrations compared to the control group 1. Significant decreases were recorded in glucose and albumin serum concentration, while significant increases in the neutrophils, monocytes, lymphocytes, globulins, urea serum concentration and in the activity of GOT in most treated groups. Doses of sulphadimidine, oxytetracycline and their combinations cleared the peripheral blood from the parasite since week 4 post treatment to the end of the experiment, while single i/m of gentamicin and its combinations with sulphadimidine and oxytetracycline cleared the parasitaemia of the peripheral blood at week 8 and 9 post treatment respectively. The present results concluded that, the drugs tested and their combinations had trypanocidal efficacy. The study recommended the possibility of treatment of trypanosomiasis with sulphadimidine, gentamicin, oxytetracycline and their combinations