GREEN CHEMISTRY APPROACH IN SYNTHESIS OF 3,4-DIHYDROPYRIMIDINONE DERIVATIVES UNDER SOLVENT-FREE CONDITIONS

Abstract

In this work, dihydropyrimidinone and their sulphur analogue dihydropyrimidinthione derivatives were synthesized by green chemistry approach in order to simplify and improve conditions that has been used traditionally to carry out the conventional Biginelli reaction for the synthesis of these derivatives. These reactions were performed by three-component condensation of different types of an aldehyde, ethyl acetoacetate, and urea or thiourea at reflux temperature under solvent-free conditions without catalyst to afford the corresponding dihydropyrimidinones and dihydropyrimidinthione in excellent yields(76–96%). Chapter one of this thesis deals basically with the green chemistry, the principles of green chemistry, green technologies. This chapter deals also with dihydropyrimidinone and dihydropyrimidinthione derivatives together with a review of their biological importance. In this work 10 dihydropyrimidinone and dihydropyrimidinthione derivatives were synthesized. The reaction course was followed by m.p and TLC technique. All the final products were subjected to UV and IR analysis. Furthermore, products were analyzed with GCMS and 1HNMR. Possible mechanistic explanation of the synthetic route together with their retrosynthetic analysis were dealt with in chapter three.