Hypercholesterolemia Due to Chronic Renal Failure in Diabetic Sudanese Patients

Abstract

This study was conducted to compare the quantitative and qualitative aspects of serum cholesterol in chronic renal failure (CRF) patients due to diabetes with that of CRF in patients due to other causes, and assessing the possibility for developing atherosclerotic cardiovascular disease. The study was conducted in 80 Sudanese patients on haemodialysis and peritoneal dialysis, 40 of them had CRF due to Diabetes mellitus and others had CRF due to other causes. Additional 40 health Sudanese served as control. Serum samples were analyzed using standard colorimetric methods to detect concentration of the total cholesterol, triglycerides, high density lipoprotein. In CRF patients due to diabetes mellitus there was significant increase in serum cholesterol level, also there was consequent decrease in high density lipoprotein. The mean of total cholesterol was 255 mg/dl in the first group and in the second was 183 mg/dl, triacylglycerols was 177 mg/dl for the first group and for the second group was 163 mg/dl, low density lipoproteins was 187 mg/dl for the first group and for the second group was 113 mg/dl, high density lipoprotein cholesterol was 27 mg/dl for the first group and 31 mg/dl for the second group. There was no effect of sex, age and the duration of renal failure. This study demonstrated the effect of diabetes mellitus on lipoprotein level in patients with CRF as one of the atherosclerotic risk factor. Keywords: chronic renal failure, diabetes mellitus, hyperlipaemia.