Detection of Lupus Anticoagulant Antibodies Among Sudanese Women With Habitual Abortion

Abstract

This study is a cross- sectional study, conducted in Khartoum state during the period from December 2013 to July 2015 to determine lupus anticoagulant among Sudanese women with habitual abortion. Onehundred and Forty patients with three or more habitual abortion were enrolled in this study and sixty healthy pregnant women without history of abortion were selected as control group. The age was ranging between 17 -45 years. Patients and control group were screened for the presence of LA by using coagulometer (CoatronM2), ACA by using enzyme linked immunosorbent assay (ELISA). The results were analyzed by using the program Statistical Packages of Social Sciences version 21 (SPSS program) and express as means. The results showed that the means of LA, Fibrinogen level and ACA for patients were (61.4± 21.6),( 265.3± 118.9) and (242.5 ± 124.3),respectively, compared to the meanof LA, Fibrinogen level and ACA forcontrol group were (36.4 ± 4.6),(255.1± 68.5) and ( 40.4± 4.5) respectively. Thirty seven of the patients (26.4 %) had lupus anticoagulant while the geographical distribution of the One hundred and Forty patientswere: 23 of them (16.4 %) from South Kurdfan. The study concluded that the presence of LA was significantly associated with habitual abortion